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Gene expression studies have revealed diagnostic profiles and upregulation of specific pathways in many solid tumors. The explosion of new information in gene expression profiling could potentially lead to the development of tailored treatments in many solid tumors. In addition many studies are ongoing to validate these signatures also in predicting response to hormonal, chemotherapeutic and targeted agents in breast cancer as well as in other tumors.   Diagnostic, Prognostic and Therapeutic Value of Gene Signatures provides readers a useful and comprehensive resource about the range of applications of microarray technology in oncological diseases. Topics covered include gene signatures and soft tissue sarcomas, prognostic relevance of breast cancer signatures, gene expression profiling of colorectal cancer and liver metastasis, gene signatures in GISTs, CNVs and gene expression profiles in pancreatic cancer, and gene signatures in head/neck, lung and gastric tumors.   Diagnostic, Prognostic and Therapeutic Value of Gene Signatures will be of great value to residents and fellows, physicians, pathologists and  medical oncologists.

Pathology --- Oncology. Neoplasms --- oncologie --- medische laboratoriumtechnologie --- pathologie --- Semiology. Diagnosis. Symptomatology --- Gene expression. --- Cancer genes. --- Cancer --- Gene Expression. --- Neoplasms --- Expression génique --- Gènes du cancer --- Genetic aspects. --- genetics. --- Aspect génétique --- EPUB-LIV-FT LIVMEDEC SPRINGER-B

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The ribosome is a macromolecular machine that synthesizes proteins with a high degree of speed and accuracy. Our present understanding of its structure, function and dynamics is the result of six decades of research. This book collects over 40 articles based on the talks presented at the 2010 Ribosome Meeting, held in Orvieto, Italy, covering all facets of the structure and function of the ribosome. New high-resolution crystal structures of functional ribosome complexes and cryo-EM structures of translating ribosomes are presented, while partial reactions of translation are examined in structural and mechanistic detail, featuring translocation as a most dynamic process. Mechanisms of initiation, both in bacterial and eukaryotic systems, translation termination, and novel details of the functions of the respective factors are described. Structure and interactions of the nascent peptide within, and emerging from, the ribosomal peptide exit tunnel are addressed in several articles. Structural and single-molecule studies reveal a picture of the ribosome exhibiting the energy landscape of a processive Brownian machine. The collection provides up-to-date reviews which will serve as a source of essential information for years to come.

Organic chemistry --- Genetics --- Molecular biology --- General biophysics --- RNA (ribonucleic acid) --- biofysica --- organische chemie --- groene chemie --- genetische manipulatie --- DNA (deoxyribonucleic acid) --- moleculaire biologie --- genexpressie --- Biomedicine. --- Gene Expression. --- Nucleic Acid Chemistry. --- Biophysics and Biological Physics. --- Medicine. --- Gene expression. --- Nucleic acids. --- Médecine --- Expression génique --- Acides nucléiques --- EPUB-LIV-FT LIVBIOLO LIVBIOMO LIVMEDEC SPRINGER-B

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The recent discoveries that established histone acetylation as a key regulatory mechanism for gene expression triggered a wave of interest in histone posttranslational modifications and led to the development of novel anticancer agents now in clinical trials. In Histone Deacetylases: Transcriptional Regulation and Other Cellular Functions, a panel of leading investigators summarizes and synthesizes the new discoveries in this rapidly evolving field. The authors describe what has been learned about these proteins, including the identification of the enzymes, the elucidation of the enzymatic mechanisms of action, and the identification of their substrates and their partners. They also review the structures that have been solved for a number of enzymes-both alone and in complex with small-molecule inhibitors-and the biological roles of the several histone deacetylase (HDAC) genes that have been knocked out in mice. Authoritative and state-of-the-art, Histone Deacetylases: Transcriptional Regulation and Other Cellular Functions constitutes a first landmark of what has been accomplished so far and sets a clear agenda for the full definition of HDAC roles in biology and disease in the years to come.

Histone Deacetylases --- Cell Cycle --- Enzyme Repression --- Neoplasms --- Sirtuins --- Histone deacetylase. --- Cell cycle. --- Enzymes. --- Cancer --- Histone désacétylase --- Cycle cellulaire --- Enzymes --- physiology. --- drug effects. --- antagonists & inhibitors. --- drug therapy. --- Chemotherapy. --- Chimiothérapie --- Cancer -- Chemotherapy. --- Histone deacetylase --- Cell cycle --- Cell Physiological Processes --- Gene Expression Regulation, Enzymologic --- Enzyme Inhibitors --- ADP Ribose Transferases --- Amidohydrolases --- Group III Histone Deacetylases --- Biological Science Disciplines --- Intracellular Signaling Peptides and Proteins --- Diseases --- Therapeutics --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Natural Science Disciplines --- Molecular Mechanisms of Pharmacological Action --- Pentosyltransferases --- Proteins --- Gene Expression Regulation --- Cell Physiological Phenomena --- Hydrolases --- Disciplines and Occupations --- Glycosyltransferases --- Amino Acids, Peptides, and Proteins --- Pharmacologic Actions --- Phenomena and Processes --- Genetic Processes --- Transferases --- Chemical Actions and Uses --- Enzymes and Coenzymes --- Genetic Phenomena --- Chemicals and Drugs --- Drug Therapy --- Histone Deacetylase Inhibitors --- Physiology --- Human Anatomy & Physiology --- Medicine --- Health & Biological Sciences --- Animal Biochemistry --- Oncology --- Chemotherapy --- Biocatalysts --- Ferments --- Soluble ferments --- Mitotic cycle --- Nuclear cycle (Cytology) --- Medicine. --- Cancer research. --- Biomedicine. --- Cancer Research. --- Antineoplastic agents --- Catalysts --- Enzymology --- Biological rhythms --- Amidases --- Treatment --- Oncology. --- Tumors --- Cancer research

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The book is of interest to academic and industrial researchers but also clinicians who are working on inflammation related topics and would like to extend their knowledge about microarrays and the application thereof. After reading the book a researcher or clinician should be in the position to plan, perform and analyse or to critically review microarray experiments related to inflammation research. So far, non of the published books covers all aspects which need to be taken into account when planning and performing a microrray experiment in inflammation research. Normally, for a researcher or clinician doing a microarray experiment it is not enough to have knowledge about microarrays , as the experiment does not start with purified and quality controlled RNA and does not end with signal intensities. Things like appropriate cell sorting techniques, stabilisation and transport of RNA or cells, the knowledge how to deal with whole blood as well as options for automation are crucial for a successful application of microarrays. Moreover these aspects are the main obstacles for transferring microarray based inflammation analysis from bench to bedside and the limiting factors for higher through put as needed in multicenter studies.

Biomedicine. --- Microarrays. --- Immunology. --- Cell Biology. --- Hematology. --- Biotechnology. --- Pharmacology/Toxicology. --- Medicine. --- DNA microarrays. --- Toxicology. --- Cytology. --- Médecine --- Puces à ADN --- Immunologie --- Toxicologie --- Biotechnologie --- Hématologie --- Cytologie --- Inflammation -- Pathophysiology. --- Inflammation -- Physiopathology. --- Oligonucleotide array sequence analysis. --- Inflammation --- DNA microarrays --- Oligonucleotide Array Sequence Analysis --- Gene Expression Profiling --- Microarray Analysis --- Pathologic Processes --- Genetic Techniques --- Molecular Probe Techniques --- Nucleic Acid Hybridization --- Sequence Analysis --- Microchip Analytical Procedures --- Pathological Conditions, Signs and Symptoms --- Investigative Techniques --- Chemistry Techniques, Analytical --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Diseases --- Biomedical Engineering --- Pathology --- Health & Biological Sciences --- Medicine --- Pathophysiology --- Pathophysiology. --- DNA biochips --- Microarrays, DNA --- Inflammatory process --- Pharmacology. --- Cell biology. --- Biochips --- Immobilized nucleic acids --- Anti-inflammatory agents --- Chemicals --- Pharmacology --- Poisoning --- Poisons --- Chemical engineering --- Genetic engineering --- Haematology --- Internal medicine --- Blood --- Cell biology --- Cellular biology --- Biology --- Cells --- Cytologists --- Immunobiology --- Life sciences --- Serology --- Toxicology --- Drug effects --- Medical pharmacology --- Medical sciences --- Chemotherapy --- Drugs --- Pharmacy --- Physiological effect